Does it support data visualization?

Yes, the skill includes scripts for generating Michaelis-Menten plots, pH/temperature profiles, and comparative heatmaps using matplotlib and seaborn.

Do I need a BRENDA account to use this skill?

Yes, you must register at brenda-enzymes.org and provide your credentials via the BRENDA_EMAIL and BRENDA_PASSWORD environment variables for the SOAP API to function.

What information can I retrieve from BRENDA using this skill?

You can access kinetic parameters (Km, kcat, Vmax), reaction equations, substrate specificities, optimal pH and temperature, inhibitors, activators, and cofactor requirements for over 45,000 enzymes.

Can this skill help with enzyme engineering?

Absolutely. It includes functions to find thermophilic homologs and pH-stable variants, helping researchers identify enzymes suited for specific industrial or experimental conditions.

BRENDA Enzyme Database Integration

Name: BRENDA Enzyme Database Integration
Author: pur3v4d3r

bypur3v4d3r

•

Data Science & ML

Accesses the BRENDA database via SOAP API to retrieve kinetic parameters, reaction equations, and organism-specific enzyme data for biochemical research.

This skill integrates the BRENDA (Braunschweig Enzyme Database) into Claude, providing comprehensive access to the world's most detailed enzyme information system. It allows researchers and developers to programmatically query kinetic data such as Km and kcat, retrieve stoichiometric reaction equations, and analyze optimal environmental conditions across over 45,000 enzymes. Designed for metabolic engineering and enzyme discovery, this skill streamlines the process of gathering scientific data for pathway reconstruction, kinetic modeling, and enzyme optimization studies by automating complex SOAP API interactions and data parsing.

Key Features

01Provides comprehensive inhibitor, activator, and cofactor requirement data

02Accesses detailed reaction equations and stoichiometry for thousands of enzymes

03Supports enzyme engineering by identifying thermophilic and pH-stable homologs

04Retrieves kinetic parameters including Km, kcat, and Vmax values

051 GitHub stars

06Compares enzyme properties and optimal pH/temperature across different organisms

Use Cases

01Gathering experimental data for kinetic modeling and Michaelis-Menten visualizations

02Identifying enzyme variants with specific industrial tolerances for bio-manufacturing

03Reconstructing metabolic pathways and performing retrosynthetic analysis

What are Skills?·How to Install

Install with 🐟 Skill.Fish

npx skillfish add pur3v4d3r/pur3-pkb-codebase brenda-database

For use in Claude.ai and ChatGPT

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