Can I get actual clinical dosing recommendations?

Yes, the skill provides access to CPIC guidelines which include evidence-based clinical recommendations and dosing adjustments based on a patient's genotype.

What types of genetic data can I query with this skill?

You can query gene information (e.g., CYP2D6), allele functions, population frequencies, phenotype assignments, and specific variant annotations using rsIDs.

What is the ClinPGx database?

ClinPGx is a comprehensive pharmacogenomics resource and successor to PharmGKB, consolidating data from CPIC, PharmCAT, and major regulatory bodies like the FDA.

Does this skill require an API key for access?

No, basic access to the ClinPGx REST API via this skill does not require authentication, though it is subject to rate limits of 2 requests per second.

ClinPGx Pharmacogenomics Database

Name: ClinPGx Pharmacogenomics Database
Author: Sologa

bySologa

0•

Data Science & ML

Queries gene-drug interactions, clinical guidelines, and genetic variant annotations from the ClinPGx database for precision medicine applications.

The ClinPGx Database skill empowers developers to integrate comprehensive pharmacogenomic intelligence into their applications. As the successor to PharmGKB, ClinPGx provides a unified API to access evidence-based clinical guidelines (CPIC/DPWG), FDA drug labels, and detailed allele functional data. This skill is particularly useful for clinical researchers and software engineers building decision-support tools that require real-time mapping of genetic profiles to actionable medication dosing recommendations and safety warnings.

Key Features

01Access CPIC guidelines for genotype-guided dosing decisions

02Analyze pharmacokinetic and pharmacodynamic drug pathways

03Explore regulatory pharmacogenomic information from FDA drug labels

04Retrieve gene-drug pairs and evidence-based clinical annotations

05Query allele functions, population frequencies, and phenotypes

060 GitHub stars

Use Cases

01Developing clinical decision support systems for personalized medicine

02Automating genomic report generation for pharmacogene panels

03Performing population-scale research on genetic drug metabolism variants

What are Skills?·How to Install

Install with 🐟 Skill.Fish

npx skillfish add sologa/codex-pipeline clinpgx-database

For use in Claude.ai and ChatGPT

Download Skill