Queries the Ensembl REST API to retrieve gene data, sequences, and variant analysis for over 250 species.
The Ensembl Genome Database skill provides a powerful interface for Claude to interact with the EMBL-EBI Ensembl genomic resource. It enables researchers and developers to perform complex genomic queries including gene symbol lookups, sequence retrieval (DNA, cDNA, and protein), and functional variant analysis via the Variant Effect Predictor (VEP). With support for over 250 species and comparative genomics capabilities, this skill is essential for identifying orthologs, analyzing evolutionary relationships, and mapping coordinates between genome assemblies like GRCh37 and GRCh38 within automated research pipelines.
Key Features
01Gene information lookup by symbol, Ensembl ID, or external identifiers
02High-throughput sequence retrieval for DNA, transcripts, and proteins
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04Genomic assembly mapping and coordinate conversion (e.g., Liftover)
05Variant consequence prediction and population frequency analysis using VEP
06Comparative genomics tools for identifying orthologs and paralogs
Use Cases
01Automating gene annotation and sequence extraction for bioinformatics pipelines
02Predicting the functional impact of genetic variants in clinical research datasets
03Conducting cross-species evolutionary analysis to identify conserved genomic regions
