Nested TAD Detection

Facilitates the identification of nested TAD and sub-TAD structures from multi-resolution Hi-C data by streamlining the workflow from raw files to standardized outputs. This skill automates the extraction of chromosome-specific dense matrices from .mcool, .cool, or .hic formats, performs necessary data quality checks, and runs the OnTAD software to generate hierarchical annotation files. It is an essential tool for genomic researchers investigating spatial regulatory architecture, boundary usage, and the enrichment of regulatory elements within inner sub-TAD structures across different cell types or conditions.

Key Features

Use Cases