Can I retrieve clinical trial status for specific drugs?

Yes, you can access clinical trial data including maximum development phases (from Phase 1 to Phase 4/Approved), trial status, and indications.

How are the association scores interpreted?

Association scores range from 0 to 1, representing the relative strength of evidence from sources like GWAS, literature, and animal models, rather than absolute probability.

What biological identifiers does this skill use?

This skill utilizes Ensembl gene IDs for targets, Experimental Factor Ontology (EFO) IDs for diseases, and ChEMBL IDs for drugs.

Do I need an API key for the Open Targets skill?

No, the Open Targets Platform GraphQL API is a public resource and does not require an API key or authentication for standard queries.

Is this skill suitable for biomarker discovery?

Yes, it provides access to RNA expression data and differential expression from the Expression Atlas to help identify potential disease biomarkers.

Open Targets Database

Name: Open Targets Database
Author: K-Dense-AI

byK-Dense-AI

•

2,188

•

Data Science & ML

Queries the Open Targets Platform to identify and prioritize therapeutic drug targets using human genetics, omics, and clinical evidence.

The Open Targets Database skill empowers researchers and developers to systematically identify and prioritize potential therapeutic targets by integrating multi-omics datasets, human genetics, and clinical trial information. By providing a programmatic interface to the Open Targets GraphQL API, it enables the retrieval of detailed target-disease associations, safety liabilities, tractability assessments, and known drug mechanisms. This skill is essential for data-driven drug discovery, allowing for the ranking of targets based on genetic evidence and the evaluation of the competitive landscape for specific indications.

Key Features

01Query genetic constraint scores (pLI, LOEUF) and pathway data

02Search for targets (Ensembl), diseases (EFO), and drugs (ChEMBL)

032,188 GitHub stars

04Assess target druggability, tractability, and safety liabilities

05Retrieve target-disease association scores across multiple evidence types

06Access clinical trial phases and mechanism of action for known drugs

Use Cases

01Safety and toxicity assessment for candidate genes during lead optimization

02Systematic target discovery and prioritization for specific therapeutic areas

03Drug repurposing research by analyzing shared mechanisms and clinical precedence

What are Skills?·How to Install

Install with 🐟 Skill.Fish

npx skillfish add k-dense-ai/claude-scientific-skills opentargets-database

For use in Claude.ai and ChatGPT

Download Skill