Does this skill require an API key?

No, the Open Targets GraphQL API used by this skill currently does not require authentication or an API key.

How does it score target-disease associations?

It aggregates evidence from multiple sources like GWAS, pathways, and animal models using a harmonic sum to provide a relative ranking score between 0 and 1.

Can I use this for clinical trial research?

Yes, it provides data on clinical trial phases (1-4), drug mechanisms of action, and known indications for various compounds.

What is the Open Targets Platform?

It is a comprehensive resource for identifying and prioritizing therapeutic targets by integrating genetics, omics, and literature data.

Which identifiers are used for searching in this skill?

The skill uses Ensembl gene IDs for targets, EFO (Experimental Factor Ontology) IDs for diseases, and ChEMBL IDs for drugs.

Open Targets Database Integration

Name: Open Targets Database Integration
Author: BbgnsurfTech

byBbgnsurfTech

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Data Science & ML

Queries the Open Targets Platform to identify therapeutic targets, analyze disease associations, and retrieve drug tractability data.

This skill enables Claude to interact directly with the Open Targets Platform, a comprehensive resource for systematic drug target identification and prioritization. By integrating human genetics, omics, and clinical data, it allows researchers and developers to evaluate target tractability, safety liabilities, and disease-target associations via the platform's GraphQL API. It is particularly valuable for drug discovery workflows, target validation, and competitive intelligence within the pharmaceutical and biotech industries, providing data-driven insights into the biological links between targets and diseases.

Key Features

01Retrieve target-disease association scores across multiple evidence types

023 GitHub stars

03Find known drugs for specific diseases along with their clinical trial phases

04Search for targets (Ensembl), diseases (EFO), and drugs (ChEMBL) identifiers

05Execute custom GraphQL queries for deep biological and chemical data retrieval

06Access detailed target annotations including tractability and safety liabilities

Use Cases

01Evaluating the safety and druggability profiles of specific human genes

02Prioritizing potential drug targets for specific diseases using genetic evidence

03Researching drug repurposing opportunities by analyzing existing indications and mechanisms

What are Skills?·How to Install

Install with 🐟 Skill.Fish

npx skillfish add bbgnsurftech/claude-skills-collection opentargets-database

For use in Claude.ai and ChatGPT

Download Skill