Can it match patients to clinical trials?

Yes, it filters active trials from ClinicalTrials.gov based on the patient's specific cancer type, biomarkers, and eligibility criteria.

How does the skill handle therapy resistance analysis?

It uses structure-based analysis (NvidiaNIM) and network-based bypass pathway analysis (IntAct) to identify why a drug may no longer be effective and suggest alternatives.

What databases does this skill access for oncology data?

It integrates data from CIViC, ClinVar, COSMIC, OpenTargets, GDC/TCGA, DepMap, and ClinicalTrials.gov.

Does it prioritize FDA-approved treatments?

Yes, the workflow specifically prioritizes FDA-approved therapies and NCCN-recommended treatments before suggesting off-label options or experimental trials.

Precision Oncology Advisor

Name: Precision Oncology Advisor
Author: mims-harvard

bymims-harvard

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1,038

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Data Science & ML

Provides evidence-based cancer treatment recommendations and clinical trial matching based on patient molecular profiles.

This skill acts as a specialized clinical decision support tool for precision oncology, enabling the interpretation of complex genetic mutations to identify targeted therapies. It synthesizes data from premier genomic databases—including CIViC, COSMIC, and ClinVar—to provide evidence-graded treatment options, analyze drug resistance mechanisms, and perform real-time clinical trial matching. By integrating multi-omic data from TCGA and DepMap, it helps researchers and clinicians bridge the gap between molecular sequencing and actionable clinical insights.

Key Features

01Analyzes therapy resistance mechanisms using structure-based and network analysis

021,038 GitHub stars

03Interprets somatic mutations, fusions, and amplifications across all cancer types

04Validates target essentiality using DepMap CRISPR knockout data

05Matches patients to active clinical trials via ClinicalTrials.gov integration

06Prioritizes treatment options based on FDA labels and NCCN evidence levels

Use Cases

01Identifying targeted therapy options for specific biomarkers like EGFR or KRAS G12C

02Automating the synthesis of molecular pathology reports into actionable summaries

03Investigating resistance pathways after a patient fails a primary line of treatment

What are Skills?·How to Install

Install with 🐟 Skill.Fish

npx skillfish add mims-harvard/tooluniverse tooluniverse-precision-oncology

For use in Claude.ai and ChatGPT

Download Skill